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KMID : 0363220090470030295
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Korean Journal of Dermatology
2009 Volume.47 No. 3 p.295 ~ p.302
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An Open Label, Multi-center Clinical Trial of Topical 5% Minoxidil Solution for the Treatment of Male Androgenetic Alopecia (A Phase IV Study)
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Park Hwa-Young
Park Jang-Kyu
Kim Do-Won
Ahn Seok-Yong
Jung Ye-Jin
Ro Byung-In
Sim Woo-Young
Park Sung-Wook
Choi Gwang-Seong
Kim Hyung-Ok
Huh Chang-Hun
Yoon Tae-Young
Kim Moon-Bum
Kim Ki-Ho
Song Hae-Jun
Yon Sook-Jung
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Abstract
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Background: Topical 5% minoxidil solution stimulates new hair growth and it helps stop the loss of hair on
individuals with androgenetic alopecia (AGA).
Objective: We wanted to assess the efficacy and safety of topical 5% minoxidil solution for treating Korean men
with AGA.
Methods: This was a 24-week, open label, clinical trial that was conducted at 14 university dermatologic centers
nationwide throughout South Korea as a multicenter study of the Korean Hair Research Society. The eligible
subjects for this study were 18- to 65 year-old men with androgenetic alopecia, as defined by the Norwood scale as
type III vertex, IV and IVA. A total of 175 men (20∼62 years old) with AGA applied topical 5% minoxidil solution
twice daily. Efficacy was evaluated by 1) the total hair count per 1 cm2 and 2) the mean hair diameter and 3) the
patient assessment and 4) the investigator assessment of the change in scalp coverage and the benefit of treatment.
Results: At week 24 as compared with baseline, there was a statistically significant increase in the total hair counts and the mean hair diameter (p＜.0001). Topical 5% minoxidil solution helped improve the investigator and patient
assessments. The topical 5% minoxidil solution was well tolerated over a 24-week period.
Conclusion: We believe that topical 5% minoxidil solution is a safe and effective drug for Korean men with AGA.
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KEYWORD
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Androgenetic alopecia, 5% minoxidil
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